Professor John Wallace

Name:	Professor John Wallace
Position:	Group Leader
Organisation:	University of Adelaide
Department/Division:	Molecular & Biomedical Science
Primary Areas:	Science and technology
Expertise:	Insulin-like growth factors; biochemistry; insulin; biotin-dependent enzymes; monoclonal antibodies; protein sequencing; protein expression.
Organisation type:	Academic
Website:	www.adelaide.edu.au
Personal Website:	www.mbs.adelaide.edu.au/people/biochem/jwalla01.html
Notes:	Alt phone: (08) 8303 5352; (08) 8303 5581 Career highlights: 1965-66:1851 Exhibition Overseas Science Scholar,Oxford University. 1969-70:Queen Elizabeth II Fellow,University of Adelaide. 1986:LKB Medal,Australian Biochemical Society 2000:Lemberg Medal,Australian Society for Biochemistry & Molecular Biology. 2001:Brailsford Robertson Lecture, CSIRO 2004:Leach Medal, Lorne Protein Conferen
Will do interviews except for:	TV (pre-recorded),TV (live)
Expert's direct contacts:
Phone:	(08) 8303 5218
This expert is available for:	Research collaboration, Consulting work, Board/committee positions

Media Contact: (Note: For journalists only)
Contact:	Candy Gibson
Phone:	+61 8 8303 3173
After Hours:	0414 559 773

Publications:	(xxv) Jitrapakdee, S., Wutthisathapornchai, A., Wallace, J.C. & MacDonald, M.J. (2010) Regulation of insulin secretion: Role of mitochondrial signalling. Diabetologia 53, 1019-1032. (xxiv) Jitrapakdee, S., St.Maurice, M., Rayment, I., Cleland, W.W., Wallace, J.C. & Attwood, P.V. (2008) Structure, Mechanism and Regulation of Pyruvate Carboxylase. Biochem J., 413, 369-387. (xxiii) Pendini, N.R., Bailey, L.M., Booker, G.W., Wilce, M.C., Wallace, J.C. & Polyak, S.W. (2008) Microbial Biotin Protein Ligases aid in understanding holocarboxylase synthetase deficiency. BBA Proteins and Proteomics, 1784, 973-982 (xxii) Jitrapakdee, S., Vidal-Puig, A. & Wallace, J.C. (2006) Anaplerotic Roles of Pyruvate Carboxylase in Mammalian Tissues. Cell and Molecular Life Sciences, 63, 843-854. (xxi) Denley, A., Cosgrove, L.J., Booker, G.W., Wallace, J.C. & Forbes, B.E. (2005) Molecular Interactions of the IGF system. Cytokines & Growth Factor Reviews, 16, 421-439. (xx) Wallace, J.C. & Barritt, G.J. (2005) Gluconeogenesis (version 2.0) Encyclopedia of Life Sciences, http://www.els.net/els/els/viewArticle...rtid=A3930. (xix) Jitrapakdee, S. & Wallace, J.C. (2004) Pyruvate Carboxylation, Transamination and Gluconeogenesis. Encyclopedia of Biological Chemistry 3, 606-610. [Ed. Lennarz W. & Lane, M.D.] [ISBN 0124437109]. (xviii) Denley, A., Wallace J.C., Cosgrove L.J., & Forbes B.E. (2003) The Insulin Receptor Isoform Exon 11- (IR-A) in Cancer and Other Diseases: A Review. Horm Metab Res. 35, 778-85. (xvii) Jitrapakdee, S. & Wallace, J.C. (2003) The Biotin Enzyme Family: Conserved Structural Motifs and Domain Rearrangements. Current Protein and Peptide Science, 4(2) 217-229. (xvi) Carrick, F.E., Forbes, B.E. & Wallace, J.C. (2002) The interaction of insulin-like growth factors (IGFs) with insulin-like growth factor binding proteins (IGFBPs), Letters in Peptide Science 8, 147-153. (xv) Attwood, P.V. & Wallace, J.C. (2002) Chemical and Catalytic Mechanisms of Carboxyl Transfer Reactions in Biotin-dependent Enzymes. Accounts of Chemical Research [American Chemical Society, Los Angeles] 35, 113-120. (xiv) Chapman-Smith, A. & Wallace, J.C. (2002) Pyruvate Carboxylase. The Encyclopedia of Molecular Medicine, [Ed. T.E. Creighton, John Wiley, USA], pp. 2695-2699. (xiii) Wallace, J.C. & Barritt, G.J. (2001) Gluconeogenesis. Encyclopedia of Life Sciences, http://www.els.net/els/els/viewArticle...rtid=A0000627 (xii) Jitrapakdee, S. & Wallace, J.C. (1999) Structure, function and regulation of pyruvate carboxylase. Biochem. J. 340, 1-16. [This paper ranked 4th among the 50 most frequently downloaded papers from the Biochemical Journal website for the 12 months to the end of January 2009] (xi) Wallace, J.C., Jitrapakdee, S. & Chapman-Smith, A. (1998) Pyruvate Carboxylase, Int. J. Biochem. & Cell Biol. 30, 1-5. (x) Ballard, F.J., Wallace, J.C., Francis, G.L., Read, L.C. & Tomas, F.M. (1996) Des(1 3)IGF I. Int. J. Biochem. & Cell Biol. 28,1085-1087. (ix) Ballard, F.J., Wallace, J.C., Francis, G.L., Tomas, F.M & Read L.C. (1996) IGF Analogues: their development and use. TODAY'S LIFE SCIENCES 8, 46-51. (viii) Wallace, J.C., Francis, G.L., Moss, J.A. Ross, M., Bagley, C.J. & Ballard, F.J. (1991) The molecular interactions of Insulin-like growth factors with their binding proteins, in MODERN CONCEPTS OF INSULIN-LIKE GROWTH FACTORS, [Ed. E.M. Spencer, Elsevier, Amsterdam] pp. 359-369. (vii) Walton, P.E., Wallace, J.C. & Ballard, F.J. (1990) The Insulin-like Growth Factors. TODAY'S LIFE SCIENCES , [Ed. R. Welling, Thomson Press, Sydney] 2, 12-18. (vi) Wallace, J.C., Bagley, C.J., May, B.L., Ross, M., Francis, G.L. & Ballard, F.J. (1989) The use of IGF analogues to determine ligand specificity of different IGF-binding proteins, in PROCEEDINGS OF INTERNATIONAL IGF-BINDING PROTEIN WORKSHOP (Vancouver) [Eds. R.L. Hintz & S.L.S. Drop, Elsevier, Amsterdam], pp.225-230. (v) Wallace, J.C. & Easterbrook-Smith, S.B. (1985) Pyruvate carboxylase: The structure of the enzyme., in PYRUVATE CARBOXYLASE, [Eds. D.B. Keech and J.C. Wallace, C.R.C. Press, Boca Raton], Ch. 3, 65-108. (iv) Wallace, J.C. (1985) Pyruvate carboxylase: Its occurrence and function in nature., in PYRUVATE CARBOXYLASE [Eds. D.B. Keech & J.C. Wallace, C.R.C. Press, Boca Raton], Ch. 2, 5-63. (iii) Wallace, J.C., Phillips, N.B.F., Snoswell, M.A., Goodall, G.J., Attwood, P.V. & Keech, D.B. (1985) Pyruvate carboxylase: Mechanisms of the partial reactions. in BIOTIN [Eds. K. Dakshinamurti & H.N. Bhagavan, New York Acad Sci., New York] Ann. N.Y. Acad. Sci. , 447, 169-188. (ii) Keech, D.B. & Wallace, J.C. (1985) How significant is homotropic cooperativity in terms of metabolic regulation ? in METABOLIC REGULATION [Eds. R.S. Ochs, R.W. Hanson & J. Hall, Elsevier Science Publishers, Amsterdam] pp. 9-14. (i) Clements, P.R., Wallace, J.C. & Keech, D.B. (1981) Synthesis of 2 Bromoacetyl CoA. in METHODS in ENZYMOLOGY, [Ed. J.M. Lowenstein, Academic Press, New York] 72, 578 579. (b) Publications - Original Research 2010 212 Duangpan S. Jitrapakdee S, Adina-Zada A, Byrne L, Zeczycki TN, St. Maurice M, Cleland, WW, Wallace JC & Attwood PV (2010) Probing the catalytic roles of Arg548 and Gln552 in the carboxyl-transferase domain of Rhizobium etli pyruvate carboxylase by site-directed mutagenesis. Biochemistry 49, 3296-3304. 211. Bailey, L.M., Wallace, J.C. & Polyak, S.W. (2010) Holocarboxylase synthetase: Correlation of protein localisation with biological function. Arch. Biochem. Biophys. 496, 45-52. 210. Brierley, G.V., Macaulay, S.L., Forbes, B.E., Wallace. J.C., Cosgrove, L.J., & Macaulay, V.M. (2010) Silencing of the IR-A favours formation of IGF-1R homodimers and enhances ligand-induced IGF-1R activation and proliferation of human colon carcinoma cells. Endocrinology 151, 1418-1427. 2009 209. Zeczycki, T.N., St.Maurice, M., Jitrapakdee, S., Wallace, J.C., Attwood, P.V. & Cleland, W.W. (2009) Insight into the carboxyl transferase domain mechanism of pyruvate carboxylase from Rhizobium etli. Biochemistry 48, 4305–4313. 208. Alvino, C.L., McNeil, K.A., Ong, S.-C., Delaine, C., Booker, G.W., Wallace, J.C., Whittaker, J. & Forbes, B.E. (2009) A novel approach to identify two distinct receptor binding surfaces of insulin-like growth factor II. J. Biol. Chem. 284, 7656-7664. 207. Kuang, Z., Yao, S., McNeil, K.A., Forbes, B.E., Wallace, J.C. & Norton, R.S. (2009) Insulin like Growth Factor-I (IGF-I): Solution Properties and NMR Chemical Shift Assignments near Physiological pH. Growth Hormone & IGF Research 19, 226-31. 2008 206. Pendini, N.R., Bailey, L.M., Booker, G.W., Wilce, M.C., Wallace, J.C. & Polyak,S.W. (2008) Biotin Protein Ligase from Candida albicans: Expression, purification and development of a novel assay. Arch. Biochem. Biophys. 479, 163-169. 205. Hasan, N.M., Longacre, M.J., Stoker, S.W., Boonsaen, T., Jitrapakdee, S., Kendrick, M.A., Wallace, J.C. & Macdonald, M.J. (2008) Impaired anaplerosis and insulin secretion in insulinoma cells caused by siRNA-mediated suppression of pyruvate carboxylase. J Biol Chem. 283, 28048-28059. 204. Gauguin, L., Delaine, C., Alvino, C.L., McNeil, K.A., Wallace, J.C., Forbes, B.E. & De Meyts, P. (2008) Alanine scanning of a putative receptor binding surface of insulin-like growth factor-I (IGF-I). J. Biol. Chem. 283: 2604 - 2613. 203. Pendini, N.R., Polyak, S.W., Booker, G.W., Wallace, J.C. & Wilce, M.C.J. (2008) Purification, crystallisation and preliminary crystallographic analysis of biotin protein ligase from Staphylococcus aureus. Acta Crystallographica F64, 520-523. 202. Bailey, L.M., Ivanov, R.A., Jitrapakdee, S., Wilson, C.J., Wallace, J.C. & Polyak, S.W. (2008) Reduced half-life of holocarboxylase synthetase from patients with severe multiple carboxylase deficiency. Human Mutation, 29, E47-57. 201. Ng, B., Polyak, S.W., Bird, D., Bailey, L.M., Wallace, J.C. & Booker, G.W. (2008) Escherichia coli biotin protein ligase: Characterisation and development of a high-throughput assay Analytical Biochemistry 376, 131-136. 200. *A. Adina-Zada,, S. Jitrapakdee,, K.H. Surinya, M.J. McIldowie, M.J. Piggott, W.W. Cleland, J.C. Wallace and P.V. Attwood (2008) Insights into the mechanism and regulation of pyruvate carboxylase by characterisation of a biotin-deficient mutant of the Bacillus thermodenitrificans enzyme. Int. J. Biochem. Cell. Biol. 40, 1743-1752. 199. Surinya, K.H., Forbes, B.E., Occhiodoro, F., Booker, G.W., Francis, G.L., Siddle, K., Wallace, J.C., & Cosgrove, L.J (2008) An investigation of the ligand binding properties and negative cooperativity of soluble insulin-like growth factor receptors. J. Biol. Chem. 283 5355-5363. 198. Brown J, Delaine C, Zaccheo OJ, Siebold C, Gilbert RJ, Van Boxel G, Denley A, Wallace JC, Hassan AB, Forbes BE, Jones EY (2008) Structure and functional analysis of the IGF-II/IGF2R interaction. EMBO J 27, 265-76. 197. Bailey, L.M. Ivanov, R.A., Wallace, J.C. & Polyak, S.W. (2008) Artifactual detection of biotin on histones by streptavidin. Anal. Biochem. 373, 71-77. 2007 196. Kuang, Z., Yao, S., McNeil, K.A., Thompson, J.A., Bach, L.A., Forbes, B.E., Wallace, J.C. & Norton, R.S. (2007) Cooperativity of the N- and C-terminal Domains of Insulin-like Growth Factor Binding Protein-2 (IGFBP-2) in IGF Binding. Biochemistry 46, 13720-13732. 195. Jitrapakdee, S., Surinya, K.H., Adina-Zada, A., Polyak, S.W., Cvetan Stojkoski, C., Smyth, R., Booker, G.W., Cleland, W.W., Attwood, P.V. & Wallace, J.C. (2007) Conserved Glu40 and Glu433 of the Biotin Carboxylase Domain of Yeast Pyruvate Carboxylase I Isoenzyme Are Essential for the Association of Tetramers. Int. J. Biochem. & Cell Biol. 39, 2120-2134. 194. St.Maurice, M., Reinhardt, L., Surinya, K.H., Attwood, P.V., Wallace, J.C., Cleland, W.W. & Rayment, I. (2007) Domain architecture of pyruvate carboxylase, a biotin-dependent multifunctional protein. Science 317, 1076-1079. 193. Boonsaen, T., Rojvirat, P., Surinya, K.H., Wallace, J.C. & Jitrapakdee, S. (2007) Transcriptional regulation of the distal promoter of the rat pyruvate carboxylase gene by hepatocyte nuclear factor 3b/Foxa2 and upstream stimulatory factors in insulinoma cells. Biochem. J. 405, 359-367. 192. Jitrapakdee, S., Adina-Zada, A., Besant, P.G., Surinya, K.H., Cleland, W.W., Wallace, J.C. & Attwood, P.V. (2007) Differential regulation of the yeast isozymes of pyruvate carboxylase and the locus of action of acetyl-CoA. Int. J. Biochem. & Cell Biol. 39, 1211-1223. 191. Delaine, C., Alvino, C.L., McNeil, K.A., Mulhern, T.D., Gauguin, L., De Meyts, P.D., Jones, E.Y., Brown, J., Wallace, J.C., & Forbes, B.E. (2007) A novel binding site for the human IGF-II/mannose 6-phosphate receptor (IGF2R) on IGF-II. J. Biol. Chem. 282, 18886-1894. 190. Denley, A.,Carroll, J.M, Brierley, G.V., Cosgrove,L., Wallace, J., Forbes, B., & Roberts, C.T. Jr., (2007) Differential Activation of Insulin Receptor Substrates-1 and -2 by IGF-Activated Insulin Receptors. Mol. Cell. Biol. 27, 3569-3577. 189. Chandrashekaran, I.R., Yao, S., Wang,C.C., Bansal, P.S., Alewood, P.F., Forbes, B.E., Wallace, J.C., Bach,L.A., & Norton, R.S. (2007) The N-terminal sub-domain of insulin-like growth factor (IGF) binding protein-6. Structure and interaction with IGFs. Biochemistry 46, 3065-74. 188. Keyhanfar, M., Booker, G.W., Whittaker, J.,Wallace, J.C., & Forbes, B.E. (2007) Precise mapping of an IGF-I binding site on the IGF-1R. Biochem. J. 401, 269-277. 2006 187. Kuang Z., Yao S., Keizer D.W., Wang C.C., Bach L.A., Forbes B.E., Wallace J.C. & Norton R.S. (2006) Structure, Dynamics and Heparin Binding of the C-terminal Domain of Insulin-like Growth Factor Binding Protein-2 (IGFBP-2). J. Mol. Biol. 364, 690-704. 186. Keyhanfar M., Forbes B.E, Cosgrove L.J, Wallace J.C. & Booker G.W. (2006) Production and Characterisation of Monoclonal Antibodies Against Insulin-like Growth Factor Type 1 Receptor (IGF-1R). Hybridoma 25, 230-7. 185. Roche P, Brown J, Denley A., Forbes B.E., Wallace J.C., Jones E.Y. and Esnouf RM (2006) A computational model for the IGF-II/IGF2R complex that is predictive of mutational and surface plasmon resonance data. Proteins: Structure, Function and Bioinformatics 64, 758-768. 184. Denley, A., Brierley, G.V., Carroll, J.M., Lindenberg, A., Booker, G.W., Cosgrove, L.J., Wallace, J.C., Forbes, B.E. and Roberts, Jr. C.T. (2006) Differential activation of insulin receptor isoforms by insulin-like growth factors is determined by the C domain. Endocrinol. 147,1029-36. 2005 183. Akekawatchai C, Holland J.D., Kochetkova M., Wallace J.C., McColl S.R. (2005) Transactivation of CXCR4 by IGF-1R in human MDA-MB-231 breast cancer epithelial cells. J Biol Chem. 280, 39701-8. 182. Jitrapakdee, S., Slawik, M., Medina-Gomez, G., Campbell, M., Wallace, J.C., Sethi, J.K., O'Rahilly, S. and Vidal-Puig, A.J. (2005) The peroxisome proliferator-activated receptor gamma regulates murine pyruvate carboxylase gene expression in vivo and in vitro. J. Biol. Chem. 280, 27466-76. 181. Carrick, F.E., Hinds, M.G., McNeil, K.A., Wallace, J.C., Forbes, B.E. and Norton, R.S. (2005) Interaction of insulin-like growth factors I and II with IGF binding protein 2: mapping the binding surfaces by NMR. J. Mol. Endocrinol. 34, 685–698. 180. Sunyakumthorn, P., Boonsaen, T., Boonsaeng, V., Wallace, J.C. & Jitrapakdee, S. (2005) Involvement of Specific Proteins (Sp1/Sp3) and Nuclear Factor Y (NF-Y) in basal transcription of the distal promoter of the rat pyruvate carboxylase gene in ?-cells. Biochem. Biophys. Res. Commun. 329, 188-196. 179. Denley, A., Wang, C.C., McNeil, K.A., Walenkamp, M.J., van Duyvenvoorde, H., Wit, J.M., Wallace, J.C., Norton, R.S., Karperien, M. & Forbes, B.E. (2005) Structural and functional characteristics of the Val44Met IGF-I missense mutation: correlation with effects on growth and development. Mol Endocrinol. 19, 711-721.